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KMID : 0043320120350071133
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Archives of Pharmacal Research
2012 Volume.35 No. 7 p.1133 ~ p.1137
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Ophiamides A-B, new potent urease inhibitory sphingolipids from Heliotropium ophioglossum
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Firdous Sadiqa
Ansari Nida Hassan
Fatima Itrat
Malik Abdul
Afza Nighat
Iqbal Lubna
Lateef Mehreen
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Abstract
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Ophiamides A (1) and B (2), two new sphingolipids have been isolated from the n-hexane subfraction of the MeOH extract of the whole plant of Heliotropium ophioglossum along with glycerol monopalmitate (3) and β-sitosterol 3-O-β-d-glucoside (4) reported for the first time from this species. Their structures were elucidated by spectroscopic techniques including MS and 2D-NMR spectroscopy. Both the compounds 1 and 2 showed potent inhibitory activity against the enzyme urease.
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KEYWORD
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Heliotropium ophioglossum, Boraginaceae, Ophiamides A and B, Urease inhibition
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